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Article
April 1929

COLDS, AND ASTHMA ASSOCIATED WITH COLDS: PREVENTIVE TREATMENT WITH VACCINES

Arch Intern Med (Chic). 1929;43(4):429-445. doi:10.1001/archinte.1929.00130270003001
Abstract

In a recent paper, Adkinson and I1 reported the results of the bacteriologic examination of the sputum of a large number of asthmatic patients, for a period of years, with special reference to the streptococcus involved. In the present paper I wish to report the clinical application of these results. Patients who were subject to colds and to asthma associated only with colds were treated with vaccines comprising the prevalent streptococci for certain periods, as determined in the earlier investigation.

During the early studies on asthma, in 1916 and 1917, numerous patients were encountered who were nonsensitive and whose asthma, which seemed to be caused by bronchial infection, was associated, however, with little if any expectoration. It was desired to treat these patients with vaccines. Sputum was not available, however, and there was no information as to the bacteria to be used. Furthermore, many patients had sporadic attacks of asthma,

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