The discovery of liver as a specific therapeutic agent in pernicious anemia1 warrants the repetition of metabolic studies that have been performed with other modes of treatment.
The protein and respiratory metabolism of five hospitalized patients with pernicious anemia was determined for periods varying from twenty to sixty-five days. These cases were under the direct supervision of Dr. Minot and Dr. Murphy, who were studying the effect of standardized liver extract and experimental liver fractions on the course of the disease. The nature of the effective fraction and the treatment of pernicious anemia with liver extract have been reported by the aforementioned observers in detail.2 Since the response of the patient to a diet of whole liver was quite similar to his response to that of liver extract, it was thought that the metabolic changes with the two methods of administration would show a close resemblance.
ALT HL. THE METABOLISM IN PERNICIOUS ANEMIA. Arch Intern Med (Chic). 1929;43(4):488–503. doi:10.1001/archinte.1929.00130270062005
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