In 1921, Van Slyke1 classified nine theoretically possible variations in the acid base balance of the blood. The bicarbonate content of the blood may be high, low or normal, and in each of these conditions the PH may be high, low or normal. All of these possibilities have been produced experimentally, and most of them have been found to occur clinically. These possibilities are illustrated in the chart by Van Slyke (fig. 1). It is in the first class that the case here described falls, that of uncompensated alkali excess.
In recent years, many cases of alkalosis have been reported in the literature, and to explain this condition various causes have been ascribed,2 as follows: (1) The administration of sodium bicarbonate, (2) pyloric or high intestinal obstruction, (3) fever, (4) deep roentgen therapy, (5) certain conditions of the gallbladder, (6) hyperpnea, (7) vomiting, (8) parathyroid deficiency and (9) nephritis associated
FRISSELL LF, DAVIS JS. ALKALOSIS OCCURRING IN ANEMIA (PROBABLY PERNICIOUS): REPORT AND COMMENT ON A CASE. Arch Intern Med (Chic). 1929;43(4):504–515. doi:10.1001/archinte.1929.00130270078006
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