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July 1929


Author Affiliations

Fellow in Medicine, the Mayo Foundation ROCHESTER, MINN.

Arch Intern Med (Chic). 1929;44(1):65-70. doi:10.1001/archinte.1929.00140010068006

Since the introduction of insulin in treatment, the symptoms of hypoglycemia have become well known. Many cases are being recognized in which hypoglycemia occurs spontaneously. As a rule, the symptoms are mild, but in a small number of cases they have been severe. The increasing incidence of the disorder and the serious disability which sometimes results make careful investigation highly important.

REPORT OF CASES  Three cases in which there was a constant tendency to severe hypoglycemia have been observed at the Mayo Clinic. I reported the first case (case 1) about two years ago in collaboration with Wilder, Power and Robertson.1 The patient had attacks of loss of consciousness, with convulsions, if he failed to receive sugar every hour during the day and night. It was demonstrated that hypoglycemia was due to overproduction of insulin from carcinoma of the islands of the pancreas.Case 2.—A farmer, aged 52, came to