The protean nature of syphilis is nowhere better illustrated than by a consideration of its visceral manifestations; in fact, the recognition of visceral syphilis by clinical means alone is often difficult if not impossible. In consequence, great emphasis has been placed on those laboratory procedures which are of assistance in showing the presence of syphilitic infection.
Although serologic tests are of great value in the recognition of visceral syphilis, they do not tell which organ is involved, or the degree of injury produced by the syphilitic process. Such information, on the other hand, would be of inestimable value in diagnosis, prognosis and treatment. Particularly is this true in cases of syphilis of the liver. Additional diagnostic measures are desirable, and the recent interest in tests for hepatic function is evidence of the need for such information.
Recent studies of the physiologic activities of the liver have served to emphasize its
O'LEARY PA, GREENE CH, ROWNTREE LG. DISEASES OF THE LIVER: VIII. THE VARIOUS TYPES OF SYPHILIS OF THE LIVER WITH REFERENCE TO TESTS FOR HEPATIC FUNCTION. Arch Intern Med (Chic). 1929;44(2):155–193. doi:10.1001/archinte.1929.00140020003001
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