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August 1929

Diabetes Latente.

Arch Intern Med (Chic). 1929;44(2):301. doi:10.1001/archinte.1929.00140020149014

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This is the inaugural dissertation of one of the assistants in Escudero's Clinic, and consists of an admirable summary of the work done by the author, his chief and many others on the peculiar manifestations of diabetes in the preglycosuric stage.

It is claimed that in normal persons the ingestion of dextrose causes a rise in the blood sugar, followed later by a considerable fall below the point where the test began. This secondary fall is caused by the fact that the carbohydrate-storing mechanism has been speeded up. Failure of the occurrence of this fall is interpreted as a deficiency in carbohydrate metabolism and is looked on as a precursor of diabetes.

Such a condition was discovered in a series of sixty-one persons suffering from skin and ocular diseases of various types. When they were subjected to antidiabetic therapy a marked improvement resulted.

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