Among the numerous constituents of the blood stream few are more closely related to many of the fundamental processes of life than the amino-acids. Yet it was only within comparatively recent times (1913) that crystalline amino-acids1 were actually isolated from the blood stream, and considerable confusion still seems to exist in regard to the amount of amino-acid nitrogen in normal and pathologic blood. Thus in a recent text on biochemistry2 the statement is found that "in diabetes mellitus there is an accumulation of amino-acids in the blood and a corresponding increased excretion into the urine. Again in nephritis there is an accumulation of amino-acids in the blood." On another page of the same book one finds the statement that "amino-nitrogen rarely rises in the blood. Even during severe nephritis there is no characteristic increase in amino-nitrogen." In a recent book on blood chemistry,3 the author said that "a definite rise
SCHMIDT EG. THE AMINO-ACID CONTENT OF THE BLOOD IN HEALTH AND IN DISEASE. Arch Intern Med (Chic). 1929;44(3):351–361. doi:https://doi.org/10.1001/archinte.1929.00140030050005
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