During the past fifteen years many investigators have concerned themselves with the problem of edema. Physical, chemical and other factors have insufficiently explained the ultimate cause of the retention of abnormal amounts of fluid in the interstitial tissues and serous cavities of the body. The final solution of the problem rests on further knowledge of factors not yet sufficiently understood, such as capillary permeability, abnormal distribution of sodium chloride and colloids, and other factors possibly of lesser importance, such as changes in H-ion concentration and hormones. The vast literature on the subject of edema includes many factors which may play a part, but the pathogenesis of this condition can be fully understood only when further correlation between them is established.1
In spite of this lack of specific knowledge, definite advance has been made in recent years in regard to methods of treatment. This has frequently been arrived at empirically, and
GOLDRING W. EDEMA IN CONGESTIVE HEART FAILURE: EFFECTIVENESS OF DIURETICS AS A GUIDE TO PROGNOSIS. Arch Intern Med (Chic). 1929;44(4):465–476. doi:https://doi.org/10.1001/archinte.1929.00140040003001
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: