The conception of disease as a product of a constitution is a heritage from antiquity, based on observation and experience.1 As is well known, the term constitution was originally used in a broad sense to denote a fixed or a prevailing state or condition. It was applied primarily to climatic and meteorological conditions, but was also used with reference to disease and to man.
To the ancient Greek, disease was a product of the interaction between man and his environment; still, environment was given first place, much as it is today, but for a different reason. The Greek regarded both man and disease as products of environment, while in recent years investigators have been inclined to disregard man and to stress the importance of a single environmental factor. This change of views is attributable to modern bacteriology. After centuries of abstract speculation concerning the cause of disease, bacteriology came like
BROWN WH. CONSTITUTIONAL VARIATION AND SUSCEPTIBILITY TO DISEASE. Arch Intern Med (Chic). 1929;44(5):625–662. doi:10.1001/archinte.1929.00140050002001
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