The clinical and morphologic features of chronic glomerulonephritis with lipoid changes are fairly well known. Often, however, such patients are studied for a short time only and during one period of the disease, usually at an advanced stage, when there are unmistakable evidences of well developed renal failure. There is, as a result, a disconnected clinical picture and a lack of appreciation of the proper sequence of events. The continuous study of a patient over a longer time usually furnishes some information that would be impossible to gather from shorter periods of observation. The illustrative case presented here was studied from the onset of the illness until death five years later. My object in this paper is to analyze the following features illustrated by the study of this case:
1. The major clinical syndromes are discussed; and it is shown that not all appear at the same time, but come