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Article
January 1930

ATELECTASIS IN THE PATHOGENESIS OF ABSCESS OF THE LUNG: A STUDY OF SPONTANEOUS PULMONARY SUPPURATION IN THE ALBINO RAT

Author Affiliations

NEW HAVEN, CONN.

From the Department of Surgery and the Laboratory of Physiological Chemistry, Yale University.

Arch Intern Med (Chic). 1930;45(1):92-101. doi:10.1001/archinte.1930.00140070099007
Abstract

Although numerous observations have been made on pulmonary infection in the albino rat, definite knowledge concerning the etiologic agent and the factors in the pathogenesis of this disease is lacking. The lesions of the lungs vary greatly according to the stage and extent of the process, but the essential nature of the completely developed lesions is that of chronic pulmonary suppuration. The late stages of the disease are frequently misnamed "pneumonia," while the earlier manifestations of the condition are imperfectly understood. The purpose of the present communication is to present a series of observations which suggest that atelectasis subsequent to bronchial occlusion is a primary factor in the development of this disease.

The literature contains numerous assertions on the one hand that the lungs are sterile, and on the other hand that they frequently contain micro-organisms. Thomson and Hewlett1 estimated that 1,500 organisms or more were taken into the air

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