We have previously shown that during the administration of 1 drop of compound solution of iodine (about 6 mg. of iodine) daily to unselected hospital patients with exophthalmic goiter, there usually occurs as marked a reduction in basal metabolism as during the administration of much larger doses.1 The effect of administering 1/2 drop of the compound solution (about 3 mg. of iodine) daily has now been observed in twenty unselected hospital patients with the disease.
The method was the same as that used in the hospital patients who received 6 mg. of iodine daily, except that 1 drop of a 50 per cent compound solution of iodine (roughly, 3 mg. of iodine)2 was administered daily in the metabolism laboratory instead of 1 drop of the undiluted solution.
The data of the twenty cases are summarized in tables 1 and 2. It may be seen that the average basal
THOMPSON WO, THORP EG, THOMPSON PK, COHEN AC. THE RANGE OF EFFECTIVE IODINE DOSAGE IN EXOPHTHALMIC GOITER: II. THE EFFECT ON BASAL METABOLISM OF THE DAILY ADMINISTRATION OF ONE-HALF DROP OF COMPOUND SOLUTION OF IODINE. Arch Intern Med (Chic). 1930;45(3):420–429. doi:10.1001/archinte.1930.00140090103006
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