We have already shown that the daily administration of about 6 mg. of iodine in the from of 1 drop of the compound solution produces a maximum reduction in basal metabolism in most hospital patients with exophthalmic goiter,1 but that the daily administration of about 3 mg. of iodine (1/2 drop of the compound solution) produces on the average only about half as much reduction.2 As a continuation of our study of the range of effective iodine dosage in exophthalmic goiter we have now investigated the effect of the daily administration of about 1.5 mg. of iodine (1/4 drop of the compound solution) in fifteen unselected hospital patients with the disease. Some observations have also been made on the effect of administering a slightly smaller dose (1/5 drop of the compound solution) to two house patients and to sixteen outpatients. Most of the outpatients had the disease in mild form.
THOMPSON WO, COHEN AC, THOMPSON PK, THORP EG, BRAILEY AG. THE RANGE OF EFFECTIVE IODINE DOSAGE IN EXOPHTHALMIC GOITER: III. THE EFFECT ON BASAL METABOLISM OF THE DAILY ADMINISTRATION OF ONE-QUARTER DROP OF COMPOUND SOLUTION OF IODINE AND OF SLIGHTLY SMALLER DOSES, WITH A SUMMARY OF RESULTS TO DATE. Arch Intern Med (Chic). 1930;45(3):430–455. doi:10.1001/archinte.1930.00140090113007
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