Observations on asthmatic persons, as well as on their reactions to drugs after the development of symptoms, have been made frequently, but we have not found any record of observations of a similar nature immediately preceding, during the development and course of, or during recovery from, an attack subsequent to the administration of a bronchodilating drug. Such an opportunity was afforded through the cooperation of one of us (J. F. F.). This subject, in whom uniform attacks could be reproduced by means of exercise (air hunger), offered the special advantage of testing the influence of the various antiasthmatic drugs on the course of the attacks under controlled and comparable conditions.
The subject was a medical student, aged 27. The asthmatic tendency was first noticed at the age of 19. The history and physical examination on entrance to the medical school showed nothing abnormal. During the course of the