[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.173.234.169. Please contact the publisher to request reinstatement.
Article
April 1930

INSULIN INACTIVATION BY HUMAN BLOOD CELLS AND PLASMA IN VITRO: EFFECT OF NORMAL AND OF DIABETIC BLOOD ON INSULIN ACTION

Author Affiliations

NEW YORK

From the Departments of Pediatrics and Laboratories of Mount Sinai Hospital.

Arch Intern Med (Chic). 1930;45(4):546-558. doi:10.1001/archinte.1930.00140100068007
Abstract

Patients suffering from diabetes mellitus are known to have periods during which they do not respond properly to insulin. It is likewise well established that diabetes becomes worse during infection, injury or operation. These observations have aroused much interest and investigation in the past few years. It is interesting that seventy-five years ago Claude Bernard1 was well aware of the danger of infection to diabetic patients.

Patients who temporarily or permanently resist insulin action are called insulin resistant or insulin refractory. The periods of resistance to insulin may be recurrent, ending in spontaneous recovery, or may be lasting, terminating in coma and death.

In July, 1925, E. K., a girl, aged 6 years, with severe diabetes, began to have peculiar reactions to insulin. On a constant diet and without any evident complication, she seemed to resist insulin action at one time and at another to have hypoglycemia on the same

×