Twenty-four cases of sprue, with a pernicious type of anemia, were studied for the purpose of contrasting these with cases with a nonmegaloblastic type of anemia, some of which were not even due to sprue.
Before consideration of these particular cases, it is necessary to state the classification on which they are based in this paper. The anemias are considered as falling into one of two divisions: (1) the nonmegaloblastic, or so-called "secondary" anemias, and (2) the megaloblastic, medullary or "primary" anemias. The distinction between these two forms of anemia has always been readily recognized in hematology, but the advent of liver as the therapeutic agent for the treatment of patients with megaloblastic anemia has brought with it a ready means of further dividing the pernicious anemias into those which yield a definite rise in reticulocytes and those which do not produce this phenomenon after treatment. For convenience, and because
ASHFORD BK. THE ANEMIAS OF SPRUE: THEIR NATURE AND TREATMENT. Arch Intern Med (Chic). 1930;45(5):647–673. doi:10.1001/archinte.1930.00140110003001
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