The use of liver and extract of liver has served to keep alive and relatively well most patients who have thus been treated regularly. In 1926, Minot and Murphy,1 in an epochal report, showed the value of feeding mammalian liver to patients with pernicious anemia. Whipple, Robscheit-Robbins and Hooper,2 in 1920, and Robscheit-Robbins and Whipple,3 in 1925, showed its value in anemia produced by repeated bleeding of animals. In 1927, Minot4 reported on the treatment of patients with an effective fraction of liver produced by Cohn. This substance brought about characteristic improvement in the condition of the blood and in the general symptoms. Minot, Cohn, Murphy and Lawson,5 in the following year, reported further on the results of treatment with extract of liver.
Porter, Williams, Forbes and Irving,6 in 1929, reported on the production of a stable, aqueous extract of liver. Sixteen of the forty-five cases reported by them were
CONNER HM. THE TREATMENT OF PERNICIOUS ANEMIA WITH AN AQUEOUS EXTRACT OF LIVER. Arch Intern Med (Chic). 1930;45(5):702–705. doi:10.1001/archinte.1930.00140110058004
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