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Article
May 1930

CHEMICAL DETERMINATION OF THE GLYCOGEN RATIO IN THE BUNDLE OF HIS AND THE CARDIAC MUSCLE IN MAN AND IN THE HORSE

Author Affiliations

WASHINGTON, D. C.; Fellow in Radiology, the Mayo Foundation ROCHESTER, MINN.

Arch Intern Med (Chic). 1930;45(5):760-771. doi:10.1001/archinte.1930.00140110116010
Abstract

For years the question of the amount of glycogen in the bundle of His, as compared with the amount in the cardiac muscle, has been discussed. The general impression, until recently at least, has been that the conduction system is comparatively rich in glycogen. This conclusion has been reached as the result of studies of microscopic sections with stains, especially Best's carmine stain. When the work on which this idea was based is analyzed, however, one feels that with the inaccurate staining methods employed the question has hardly been settled.

REVIEW OF SIGNIFICANT LITERATURE  Best,1 in 1903, published the results of a study on glycogen and described a method of staining which he considered to be fairly specific for glycogen. He found that a carmine stain of unknown chemical composition was taken up by certain granules present in the fixed tissues of the liver, of striped muscle, of tumors and

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