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Article
May 1930

PANCREATIC FUNCTIONV. THE SECRETORY MECHANISM OF DIGESTIVE JUICES

Arch Intern Med (Chic). 1930;45(5):783-813. doi:10.1001/archinte.1930.00140110139012
Abstract

In the foregoing paper1 we noted that hypoglycemia provokes the gastric, pancreatic and biliary secretions, and that hyperglycemia inhibits these. Since hypoglycemia induces humorally an excitatory impulse and hyperglycemia an inhibitory impulse to the secretory center, since from this center the stimulus and the inhibitory impulse are transmitted through the autonomic nervous system to the acting tissue cells, and since this phenomenon plays an important rôle as a regulatory mechanism in the process of gastric, pancreatic and biliary secretion, we called this phenomenon the "humoroneural regulation of the secretion of digestive juices." It is proved that the salivary secretion is excepted from this regulation. Furthermore, in dogs provided with a Thiry-Vella fistula, the secretion of the intestinal juice does not show this regulatory mechanism. It is well known that the alimentary hyperglycemia is usually due to the increase of dextrose in the blood. Therefore it is of interest to know

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