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In this monograph, the authors present the results of their clinical studies of the blood and plasma volumes with the dye method of Rowntree, Keith and Geraghty.
The first four chapters are devoted to a discussion of the method, and careful consideration is given to the criticisms which have been made against it. From the evidence presented it seems justifiable to conclude that the method, while not ideal, is a practical procedure which should yield fairly reliable results. The reliability of the hematocrit readings has been increased by the adoption of Whipples' procedure involving the use of 1.6 per cent of sodium oxalate solution.
In chapter 5 are presented the values for seventy-four normal subjects. The remaining chapters are devoted to the consideration of the values obtained in 250 cases of various diseases. The authors have chosen to interpret their results on the basis of variations in the mean values
The Volume of the Blood and Plasma in Health and Disease.. Arch Intern Med (Chic). 1930;45(5):825. doi:10.1001/archinte.1930.00140110181017