Several workers have suggested that abnormalities in calcium metabolism may be significant in the genesis and development of neoplasms in man and in other animals. Thus Clowes and Frisbie1 found calcium to be markedly low and potassium high in actively growing malignant tissue. Goldzieher2 and Theis and Benedict3 reported low values for the total serum calcium in patients afflicted with carcinoma and other malignant tumors. Reymond, Sendrail and Lassalle4 and Sendrail5 claimed that a lowering of the serum calcium occurred in the precancerous phase of animals with experimentally induced neoplasms. Finally, McDonald6 went so far as to state that cancer is a disease associated with a lessened amount of total and ionized calcium in the blood. These observations led us to investigate the calcium fractions, the proteins and the inorganic phosphate of the blood serum in fifteen patients suffering from malignant diseases.
Recent work in the field of calcium metabolism7
GUNTHER L, GREENBERG DM. II. THE DIFFUSIBLE CALCIUM AND THE PROTEINS OF THE BLOOD SERUM IN MALIGNANT DISEASES. Arch Intern Med (Chic). 1930;46(1):67–71. doi:10.1001/archinte.1930.00140130070005
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