In an attempt to explain the etiology of nonspecific chronic arthritis, there have emerged widely conflicting opinions based, at times, entirely on clinical or laboratory observations. But in view of the lack of definitive conclusions, it seems desirable to correlate our laboratory observations with clinical observations to determine what light may be shed on this rather perplexing problem.
The opinions of most writers in recent years have begun to lean toward the primarily infectious nature of chronic arthritis. Although, admittedly, the modus operandi of such infections has not been clarified, a great amount of reliable data has already accumulated in support of the infectious theory. Clinically, the frequent occurrence of arthritis in the course of acute infections such as scarlet fever, typhoid fever, malta fever, ulcerative colitis, and so forth, is well recognized. The extensive researches of Rosenow1 and his co-workers2 have emphasized the rôle of focal infection in arthritis
MARGOLIS HM, DORSEY AHE. CHRONIC ARTHRITIS: BACTERIOLOGY OF AFFECTED TISSUES. Arch Intern Med (Chic). 1930;46(1):121–136. doi:10.1001/archinte.1930.00140130128009
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