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This monograph represents a rather violent reaction to the Starling-Epstein theory of edema and the whole concept of the rôle of mechanical forces in the fluid exchange between the blood and the tissues. Following the school of Kraus and Zondek, the author presents the evidence and the arguments in favor of a regulatory center for water balance situated in the hypothalamus. This center acts through nervous pathways and by means of the "hormone" of the intermediate and posterior lobes of the hypophysis on the "constellation of electrolytes" in the cells of the various organs, tissues and vascular structures involved in water balance. The whole purpose of this regulation is to keep the volume of the blood plasma constant. The chief stimulus to the center is an increase in, or a threat to increase, the water content of the blood. Oliguria, of acute nephritic or cardiac origin, is the most important
Edema and Its Treatment.. Arch Intern Med (Chic). 1930;46(1):162–163. doi:10.1001/archinte.1930.00140130169012