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Article
September 1930

CHEMISTRY AND METABOLISM IN EXPERIMENTAL YELLOW FEVER IN MACACUS RHESUS MONKEYSII. NITROGEN METABOLISM

Author Affiliations

NEW HAVEN, CONN.

Arch Intern Med (Chic). 1930;46(3):382-401. doi:10.1001/archinte.1930.00140150023003
Abstract

In the preceding paper,1 determinations of nonprotein nitrogen and its individual nitrogenous components in the blood of normal Macacus rhesus monkeys and similar animals infected with yellow fever were presented. It was shown that in the terminal stage of yellow fever, the amino-acid nitrogen in the blood increased greatly, both in absolute magnitude and in proportion to total nonprotein nitrogen and other individual nitrogenous constituents. Urea nitrogen, on the other hand, did not rise, or rose little in proportion to amino-acid and total nonprotein nitrogen. In a few instances it actually diminished. The nature of the observed changes indicates that the chief disturbance of nitrogenous metabolism in yellow fever is the destruction or impairment of the power of the liver to deaminize amino-acids and to form urea.

However, definite conclusions cannot be drawn from studies of the blood alone. In order to estimate the rates of formation and destruction of

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