The conception of local immunity, i.e., the locally increased resistance of a tissue or organ without the participation of the organism as a whole, is not a new one. It has long been recognized that the tissue cell, as the ultimate functional body unit, must be the source from which originate the various protective constituents of normal and immune serums, and that it must be in these cells that the primary changes of the processes known as immunization take place. In support of this view there are both clinical and experimental data; of the former, one notes, for example, the occurrence of crops of furuncles in widely different parts of a patient's skin, one crop healing only to have another crop arise; there the process of limitation and healing of the infected foci is surely not due to any generalized resistance, but rather to local causes. On the experimental side
FRISCH IA. DEMONSTRATION OF LOCAL IMMUNITY OF THE PERITONEUM BY MEANS OF THE SHWARTZMAN PHENOMENON. Arch Intern Med (Chic). 1930;46(3):410–416. doi:10.1001/archinte.1930.00140150051005
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