Numerous methods for counting blood platelets have appeared since Schultze's1 original description in 1865 of these "granular formations" as microscopic cellular constituents of normal blood. Hittmair2 in his recent review of the literature referred to twenty new methods that had appeared within the previous ten years. That these methods are for the most part unsatisfactory is indicated by the wide range of supposedly normal figures reported, as shown in table 1.
These wide differences may be explained by improper technic, which involves two kinds of errors: (1) loss or destruction of blood platelets and (2) the inclusion in preparations of artefacts and foreign matter which are mistaken for platelets. The first results in counts too low, the second in counts too high. The difficulties encountered by various investigators are undoubtedly due to the peculiar physical characteristics of the platelets; viz., their great tendency to agglutination, adhesion and easy disintegration, which
OLEF I. BLOOD PLATELETS: AN IMPROVED INDIRECT METHOD FOR THEIR ENUMERATION. Arch Intern Med (Chic). 1930;46(4):585–596. doi:10.1001/archinte.1930.00140160035004
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