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November 1930


Author Affiliations

With the Technical Assistance of Miss Mary Beard MONTREAL, CANADA

From the Department of Metabolism, the Montreal General Hospital.

Arch Intern Med (Chic). 1930;46(5):752-767. doi:10.1001/archinte.1930.00140170013002

The primary purpose of this investigation was to attempt to find the cause of wide discrepancies met with occasionally between the cholesterol content of the blood and the clinical picture in diabetes mellitus. Theoretical considerations led to a physicochemical study of the blood of such patients. The results obtained appear to be not only of clinical, but of biologic, interest in general.

Determination of the cholesterol content of blood plasma has been a routine procedure in the diabetic clinic of the Montreal General Hospital for a number of years.1 As with all other laboratory tests, with the accumulation of data and their correlation with the clinical states, anomalous results are met with that cannot be accounted for by technical error. For example, high cholesterol values may be found in the absence of conditions with which they are usually associated in diabetes (severe diabetes, acidosis, ingestion of food of high sterol

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