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February 1931


Arch Intern Med (Chic). 1931;47(2):182-195. doi:10.1001/archinte.1931.00140200018002

The intimate relationship of the liver to the pancreas, together with its association in carbohydrate metabolism, gives at least some justification for the assumption that hepatic dysfunction may be of frequent occurrence in diabetes mellitus. In an effort to corroborate or refute this supposition, the function of the liver in 100 persons with diabetes has been studied.

A review of the literature shows that numerous articles have been written concerning hepatic function and tests for the estimation of it. but only a few investigators have reported determinations in diabetic patients. Joslin1 stated:

The liver is assuming more and more the prominent rôle which it played in diabetes in the time of Claude Bernard. Its influence for good or evil, perhaps measured by the amount of glycogen which it stores, is more and more acknowledged. Perhaps the great "factor of safety" which the liver possesses because of its size hides its

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