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Because of the great advance in knowledge of pernicious anemia and its treatment, a monograph on the subject is not only warranted but desirable. The recent discovery of liver therapy was not accidental, but came to fruition through painstaking research by many persons which culminated in the experimental treatment, by Whipple and his collaborators, of animals with anemia with a diet of liver and the clinical application of the principles to patients by Minot and Murphy in 1926. In addition to this therapeutic advance, great gains have been made during the past decade in knowledge of the formation of blood, the destruction of blood and the metabolism of pigment. Refined methods in hematology, bacteriology and biochemistry have all added their quota. Unfortunately, this new and useful knowledge has failed to answer many questions concerning the etiology and pathogenicity of the disease but has, on the contrary, opened up many new
Pernicious Anemia. Arch Intern Med (Chic). 1931;47(3):511. doi:10.1001/archinte.1931.00140210174016
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