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May 1931

Die Entzündliche Grundlage DER TYPISCHEN Geschwürsbildung IM Magen UND Duodenum.

Arch Intern Med (Chic). 1931;47(5):825. doi:10.1001/archinte.1931.00140230152012

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This is a monograph of 155 pages in which are excellently presented the results of the ten year study of ulcer by Konjetzny and his associates, particularly Kalima and Puhl. It begins with a concise review of the older theories of the etiology and pathogenesis of ulcer and then proceeds at once to the investigations carried out in their clinic at Kiel on fresh material obtained at the operating table and submitted to careful histologic study.

The first question asked is whether or not ulcer develops in a previously normal mucosa. It is answered in the negative. Erosions and acute ulcers always accompany chronic ulcers, and they occasionally produce the ulcer syndrome without the presence of a chronic ulcer. These erosions and acute ulcerations are due to an inflammatory process in the mucosa, a gastritis and duodenitis. The erosion develops as the result of polymorphonuclear infiltration just beneath the epithelial

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