It has been found that liver or liver extract used in the treatment for pernicious anemia has an effect on the blood only; it has no effect on either the achylia or the sclerosis occurring in the posterior and lateral columns of the spinal cord.
There is a tendency to interpret the favorable remissions obtained in the condition of the blood in patients with pernicious anemia treated by liver substance as having some enlightening implications concerning the etiology of the disease. It is easy to say, when these remissions are universally obtained, that some deficiency is being supplied to the patient with pernicious anemia and that therefore the condition must be a deficiency disease. One must not forget, however, that pernicious anemia, as now generally known, presents other important pathologic changes than those seen in the blood. The changes in the blood themselves are of a hemolytic character, as can
CAREY JB. PERNICIOUS ANEMIA WITH FATAL TERMINATION DURING A LIVER DIET: REPORT OF THREE CASES. Arch Intern Med (Chic). 1931;47(6):893–900. doi:10.1001/archinte.1931.00140240066006
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