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July 1931


Author Affiliations


From the Medical Clinic of the Peter Bent Brigham Hospital and the Medical Laboratories of the Harvard Medical School.

Arch Intern Med (Chic). 1931;48(1):51-69. doi:10.1001/archinte.1931.00150010056003

The Starling hypothesis, which holds that the exchange of water between the blood and the tissue fluids through the capillary wall is determined by a delicate balance between the hydrostatic pressure in the capillaries and the osmotic pressure of the plasma proteins, has been almost definitely established by research work, both experimental and clinical. In 1926, Landis1 measured the capillary pressure by introducing the micropipet into the capillaries of the mesentery of the frog, and found a gradient of pressure ranging from 14.5 cm. of water at the arterial end to 10 cm. at the venous end. He found that filtration outward occurred when the pressure was above 11.5 cm. of water. White2 found the osmotic pressure of the plasma proteins of the frog to be from 10 to 12 cm. of water. Recently Landis3 (1930) measured the capillary blood pressure in human skin and found that

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