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This monograph contains a well organized and critical summary of the present available information on the influence of the sensory nerves distributed to the heart, the aorta, the carotid sinus and other blood vessels, and on the reflex regulation of the heart itself and of the blood vessel musculature in health and in disease. That sensory nerves distributed to the walls of the ventricles and to the aorta contribute to cardiovascular reflex control has long been known. A number of years ago the work of a German physician, Hering, brought out the fact that there is an additional pronounced sensory region at the bifurcation of the carotids (the so-called carotid sinus) from which sensory impulses play a marked rôle in the cardiovascular reflexes. Later, though still fragmentary, information indicates that probably all blood vessels are supplied with afferents having important cardiovascular reflex function. The disturbance of these mechanisms in such