In various types of chronic nephritis there develops a disturbance of the inorganic metabolism that is dependent, in part at least, on impairment of renal function. Sooner or later this disturbance is complicated to a variable degree by any or several of such concomitant disturbances as loss of appetite, vomiting, albuminuria and edema. On account of the discouraging number of variables encountered in clinical nephritis, Atchley and Benedict1 studied the influence of obliteration of renal function in dogs by means of ligation of both ureters; they expressed the belief that they had produced the picture of uncomplicated renal insufficiency.
The plan of the present contribution was to study the inorganic disturbance in cases of clinical nephritis in which complications were relatively slight. Observations were made over a period of three years during intervals when disturbing influences for the most part seemed negligible. Appetite was not infrequently poor, but there
BRIGGS AP. THE ACIDOSIS OF NEPHRITIS: ITS CLINICAL SIGNIFICANCE. Arch Intern Med (Chic). 1932;49(1):56–76. doi:10.1001/archinte.1932.00150080059004
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