We have previously shown that in Boston the daily administration of about 6 mg. of iodine in the form of the compound solution produces a maximum reduction in basal metabolism in most hospital patients with exophthalmic goiter,1 and that the daily administration of about 3 mg. produces on the average only half as much reduction2 and the daily administration of about 1.5 mg. on the average only one-third as much reduction.3 As a continuation of our study of the range of effective iodine dosage in exophthalmic goiter we have now investigated the effect of the daily administration of about 0.75 mg. of iodine in twelve unselected hospital patients with the disease.
METHOD AND RESULTS
Method.—The same routine was followed as with the hospital patients in the first paper of this series,1 except that 1 drop of a 12.5 percent compound solution of iodine (about 0.75 mg. of iodine)4 was
WILLARD OWEN THOMPSON, PHEBE K. THOMPSON, ARCHIBALD C. COHEN. THE RANGE OF EFFECTIVE IODINE DOSAGE IN EXOPHTHALMIC GOITERIV. THE EFFECT ON BASAL METABOLISM OF THE DAILY ADMINISTRATION OF ABOUT 0.75 MG. OF IODINE. Arch Intern Med (Chic). 1932;49(2):199–214. doi:10.1001/archinte.1932.00150090029004