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Article
February 1932

CINCHOPHEN POISONING: AN ATTEMPT TO PRODUCE TOXIC CIRRHOSIS OF THE LIVER IN RATS

Arch Intern Med (Chic). 1932;49(2):215-220. doi:10.1001/archinte.1932.00150090045005
Abstract

In a previous paper1 two cases of toxic cirrhosis were described that were observed clinically and examined at autopsy in the Cleveland City Hospital. Reports of many cases have since then appeared in the literature; cinchophen and its allies may now be regarded as drugs of considerable potential toxicity. Nevertheless, it remains true that cinchophen is used extensively without any apparent ill effects. It is, therefore, of considerable importance that the mechanism of the drug's toxic action be explained.

EXPERIMENTS  Adult albino rats were used in these experiments. They were fed dried whole milk, whole wheat flour, calcium carbonate, sodium chloride (Sherman's diet B) and weekly additions of meat and greens. In many of the rats infections of the upper and lower respiratory tracts developed, such as purulent bronchitis, pneumonia with atelectasis and disease of the middle ear, which were found with equal frequency among the controls.The lethal

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