That nitrites have some action on the gastro-intestinal tract was first called to my attention in July, 1926, when a patient, who was being treated in the hospital by the Sippy method for a duodenal ulcer, complained of precordial pain. The intern interpreted this pain as angina pectoris because he found a slight elevation of the blood pressure during these attacks. For this reason amyl nitrite was given to the patient to inhale. The pain was relieved promptly. During a subsequent attack of pain a duodenal tube was passed, and aspiration of the gastric contents, which were high in acidity, gave as prompt relief as the amyl nitrite. An increase in the dose of alkalis stopped the attacks.
This experience led me to investigate the effect of nitrites on the gastro-intestinal tract in other patients who were suffering with disease of the stomach and intestines.
This study comprises two
BEAMS AJ. THE EFFECT OF NITRITES ON PAIN AND ON THE MOTILITY OF THE GASTROINTESTINAL TRACT: I. CLINICAL STUDY. Arch Intern Med (Chic). 1932;49(2):270–275. doi:10.1001/archinte.1932.00150090100011
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