Since Pauli's1 observation in 1903 that thiocyanate is effective in reducing high blood pressure, the use of this drug has apparently gained favor. Frequent confirmation of this observation, particularly in recent years, seems to have caused rather general acceptance of thiocyanate therapy as offering, in a selected group of persons with hypertension, a method of meeting a difficult therapeutic problem. Ever since Claude Bernard's2 first pharmacologic investigation, in 1857, there have been many references to the toxic properties of thiocyanate, but in examining the literature it is noteworthy that, with a few exceptions, mainly its hypotensive property is stressed. The appearance of toxic manifestations thirteen times in a series of seventy-four trials in fifty patients under investigation by us seemed of sufficient importance to report. In two of these thirteen patients there was a fatal outcome. We believe that this is the first report of death in man
GOLDRING W, CHASIS H. THIOCYANATE THERAPY IN HYPERTENSION: I. OBSERVATIONS ON ITS TOXIC EFFECTS. Arch Intern Med (Chic). 1932;49(2):321–329. doi:10.1001/archinte.1932.00150090151015
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