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Article
March 1932

AVITAMINOSIS: IV. THE EFFECT OF A DEFICIENCY OF THE VITAMIN B COMPLEX ON THE LIPID METABOLISM AND GLYCOGEN CONTENT OF THE LIVER OF THE ALBINO RAT

Author Affiliations

FAYETTEVILLE, ARK.

From the Departments of Agricultural Chemistry and Home Economics, University of Arkansas.

Arch Intern Med (Chic). 1932;49(3):397-404. doi:10.1001/archinte.1932.00150100054003
Abstract

In previous communications we have demonstrated that the main biochemical changes in the albino rat suffering from a deficiency of the vitamin B complex are anhydremia associated with a disturbance in hematopoietic function1 and, in uncomplicated vitamin B deficiency, a marked reduction in the glycogen content of the liver.2 Since in such avitaminosis the most pronounced symptom complex is anorexia, the tentative conclusion made was that the pathologic changes encountered may have been, at least in part, produced indirectly through a reduction in food consumption. In this and in the communication following, experimental evidence is submitted on studies carried out by a method which eliminated the plane of nutrition as a complicating factor. Weaned albino rats, weighing from 50 to 60 Gm. and about 4 weeks of age, were transferred from our stock diet 13 to diet 1751, satisfactory in every respect, with the exception of vitamin

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