In a recent communication Sure, Thatcher and Walker1 have reported that in uncomplicated vitamin B deficiency there are produced a lymphopenia and a corresponding polymorphonuclear leukocytosis. The conclusion was, however, tentatively reached that such changes may be an expression of inanition. In this article we are submitting evidence showing that such a phenomenon is a manifestation of a deficiency of vitamin B per se.
Three groups of littermate rats of the same sex were studied in sets of four. The first animal received a diet satisfactory in every respect with the exception of vitamin B, 10 per cent autoclaved dehydrated yeast in the ration having supplied an adequacy of vitamin G. The second animal received the same diet and was restricted to the same amount of food and water daily as the first, but instead received the same proportion of untreated yeast in the ration, thus being supplied an
SURE B, WALKER DJ. AVITAMINOSIS: V. THE SPECIFIC EFFECT OF VITAMIN B DEFICIENCY ON THE DIFFERENTIAL COUNT OF THE ALBINO RAT. Arch Intern Med (Chic). 1932;49(3):405–408. doi:10.1001/archinte.1932.00150100062004
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