In the human female the process of menstruation is accompanied by a train of phenomena of which the uterine changes are only a part. Thus, pain and nervous and congestive reactions may at times become very pronounced. These various activities of the organism usually increase in intensity a few days before the menstrual flow begins, to diminish again toward the close of the period. A second lesser maximum may occur a few days after the flow has ceased. Naturally, much attention has been centered on the changes in the peripheral blood and blood-forming organs during menstruation, but the reports have been somewhat confusing. The quantity of blood lost during a normal period is also a subject of considerable discussion. Kelly1 stated that the amount is from 60 to 240 cc.; Crossen2 gave it as from 150 to 300 cc., and Howell,3 from 100 to 200 cc., while
REICH C, GREEN D. RED CELL REGENERATION DURING THE MENSTRUAL CYCLE. Arch Intern Med (Chic). 1932;49(3):534–538. doi:10.1001/archinte.1932.00150100191012
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