The syndrome first described by Schultz1 as agranulocytosis was considered by him to represent a definite clinical entity. Other observers who also held this view based their opinions on the fairly uniform clinical history, particularly the age and sex predilection and the peculiarity in the distribution of the supposedly specific lesions. However, subsequent contributions have indicated that a similar hematologic picture occurs with varying clinical features and apparently is based on a variety of causes. Later observations have strengthened the view that the disease is symptomatic of a number of etiologic factors, such as infection, chemical agents and the action of x-rays and radium. The protagonists of the theory that the disease is a distinct entity believe: (1) that it represents a specific primary disease or infection of the granulopoietic structure in the bone marrow with the necrotic lesions in the mouth as an expression (Schultz), or (2) that
PIERSOL GM, STEINFIELD E. GRANULOPENIA (GRANULOCY TOPENIA): WITH SPECIAL REFERENCE TO CLASSIFICATION AND BENIGN TYPES. Arch Intern Med (Chic). 1932;49(4):578–588. doi:10.1001/archinte.1932.00150110039002
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