It has already been pointed out that in the last stages of fatal yellow fever in Macacus rhesus the urinary excretion of organic acid and phosphates is considerably increased.1 In the present paper are reported the results of more extensive studies of the acid-base and electrolyte equilibrium in this disease.
The general experimental procedures outlined in the first paper of this series2 have been carefully followed.The electrolytes of the serum were determined by procedures essentially the same as those described by Peters, Wakeman, Eisenman and Lee.3 Blood was withdrawn and serum separated, with anaerobic precautions, by the technic of Austin and his co-workers.4Blood was collected without stasis from the heart, the femoral artery or the veins of the upper extremities. In certain of the normal animals attempts were made to withdraw venous blood without anesthesia. However, it soon became evident from the low
WAKEMAN AM, MORRELL CA. CHEMISTRY AND METABOLISM IN EXPERIMENTAL YELLOW FEVER IN MACACUS RHESUS MONKEYS: V. ACID-BASE AND ELECTROLYTE EQUILIBRIUM. Arch Intern Med (Chic). 1932;49(5):826–835. doi:10.1001/archinte.1932.00150120116011
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