It came to my attention about two years ago, as previously reported in the Archives,1 that the Boltz test for tryptophan may be applied directly to urine, and, as very few data on the incidence of tryptophan in urine are available, it seemed to me that this problem was one worthy of the expenditure of some time and energy. This paper is consequently a report of the results of 169 tests on 10 normal controls, indicating that tryptophan is not eliminated in the urine of the normal man in health and on an average diet; of 525 tests on specimens sent to the laboratory for routine examination from general surgical and medical cases, and of over 600 tests on specimens from cases of nervous and mental diseases—all accumulated during the past eighteen months.
An essential improvement in the technic of the original Boltz test when employed in urinalysis has
BRICE AT. TRYPTOPHANURIA AND ITS SIGNIFICANCE: A PRELIMINARY REPORT. Arch Intern Med (Chic). 1932;49(6):978–980. doi:10.1001/archinte.1932.00150130101008
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