The present investigation was conducted in an attempt to determine whether in the absence of pancreatic or hepatic disease the concentration of the total blood lipid at fixed intervals after the ingestion of a large amount of fat adhered to a typical pattern. If a typical curve were demonstrated, a method similar to the dextrose tolerance test could then be employed to discover what modifications were produced by such disease. The total blood lipid was chosen as an indicator of lipolytic activity largely because it could be estimated by a relatively simple method requiring only small amounts of blood.
The procedure was as follows: After a twelve hour fast, a specimen of blood was withdrawn. The subject immediately thereafter drank 100 cc. of olive oil. Samples of blood were then taken two, three, four, five and six hours after the ingestion of the oil. In many instances, the fifth
WECHSLER HF. VARIATIONS IN THE TOTAL BLOOD LIPID IN ALIMENTARY LIPEMIA. Arch Intern Med (Chic). 1932;50(1):37–45. doi:10.1001/archinte.1932.00150140044003
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