The efficiency of sodium bismuth tartrate as a clinical diuretic and antiedemic has been sufficiently demonstrated in previous studies.1 It appeared desirable to throw light, if possible, on the mechanism of these actions. It was especially desired to ascertain if the tissues in general might be the seat of the bismuth action. This was tried by attempts to correlate the changes in the metabolites, especially the chlorides of the blood and urine, with the diuretic action. Such an attempt on healthy rabbits indicated a tissue action of the bismuth.2 The same was found to be true not only for bismuth, but also for theophylline, and possibly digitalis, in human subjects discussed in a preliminary report.3 This paper presents various data and details of the results in patients with and without edema receiving bismuth.
The results with bismuth were obtained in a total of fifteen different patients
STOCKTON AB. BISMUTH DIURESIS AND THE BLOOD AND URINARY CHANGES UNDER CLINICAL CONDITIONS. Arch Intern Med (Chic). 1932;50(1):142–149. doi:10.1001/archinte.1932.00150140149009
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