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Article
July 1932

EXPERIMENTAL LOW COLONIC OBSTRUCTION

Author Affiliations

CHICAGO

From the Department of Medicine and the Department of Physiology and Pharmacology, Northwestern University School of Medicine.

Arch Intern Med (Chic). 1932;50(1):150-157. doi:10.1001/archinte.1932.00150140157010
Abstract

Recent experimental work has emphasized the importance of chloride metabolism in high intestinal obstruction and has offered much of value in the treatment for this condition. Relatively few studies have been made on obstruction low in the large bowel, which produces a somewhat different though not fundamentally dissimilar syndrome. It was felt that a careful study of low obstruction might supplement our knowledge of intestinal obstruction in general by bringing out similarities and differences between low and high obstruction, and might possibly yield information of practical importance for therapy.

McClure,1 in 1907, produced colonic obstruction by ligation with a cotton cord. Vomiting was prominent, although no food or drink was taken postoperatively. The animals were very drowsy, and the symptoms were progressive; the average length of life was seven days. Dilatation just above the ligature was often enormous, and was uniform up to the ileocecal valve, above which the

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