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August 1932


Author Affiliations


From the Department of Internal Medicine and the Department of Pathology of Yale University and the Medical Service of the New Haven Hospital.

Arch Intern Med (Chic). 1932;50(2):232-239. doi:10.1001/archinte.1932.00150150064007

Since Troisier's1 description in 1871 of a case of "diabéte sucré" with pigmentary changes, approximately 175 cases of hemochromatosis have been reported. Fourteen, or 9 per cent, of the 153 cases from the literature with data available for study, exhibited some degree of purpura, while in an additional 9 cases, or 6 per cent, hemorrhagic manifestations other than purpura developed in the course of the disease. Other authors have discussed this occurrence and have speculated on its importance in the etiology of the pigment deposits that are characteristic of the disease. In spite of this incidence of purpura in hemochromatosis, it is not generally mentioned as a frequent symptom.

The necropsy records of the department of pathology of the New Haven Hospital between 1917 and 1930 contain reports of 5 cases of hemochromatosis, all of which occurred in males. Two of the patients, at the time of admission, had

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