The fact that heart disease is associated with fibromyoma of the uterus is well known. The discussions of this association introduced by Hoffmeir1 and continued by some of the early authors—Leopold,2 Fehling,3 Brosin,4 Hennig,5 Landau,2 Kessler,6 Wilson,7 Doran,8 Chavanez9 and others—still continues. The more extensive and thorough work of later investigators—Boldt,10 Healy,11 Garkisch,12 Strassmann and Lehmann,13 Kelly and Cullen14 and Janaki15—points to a frequency of simultaneous occurrence of the two conditions ranging from 20 to 40 per cent. Such a high figure does not seem to apply to carcinoma or other diseases of the uterus or its appendages. This statistical concomitance has warranted the belief on the part of some gynecologists and internists that the new growth can specifically or uniquely injure the heart. Hoffmeir,1 Brosin,4 Strassmann and Lehmann,13 von Lingen,16 Henning,5 von Müller17 and others stated this opinion. On the other hand some authors have denied this relationship. Severe critics
BRANDMAN H. FIBROMYOMA OF THE UTERUS, CARDIAC FAILURE, ANEMIA AND EDEMA: REPORT OF A CASE. Arch Intern Med (Chic). 1932;50(2):306–316. doi:10.1001/archinte.1932.00150150138013
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