The pain of peptic ulcer is usually ascribed to one of two causes: gastric acidity or gastric hunger contractions. Ginsburg, Tumpowsky and Hamburger1 ascribed the pain of ulcer to the increased gastric tension and correlated the pain with gastric hunger contractions. Carlson2 also showed that the pain in ulcer was synchronous with hunger contractions. Reynolds and McClure3 examined patients fluoroscopically, and found no relation between the gastric contractions and the pain in ulcer. Ortmayer's4 observations related the pain to gastric acidity. Palmer5 studied the subject extensively and reported a definite relation of gastric acidity to pain in gastric and duodenal ulcer. He found that the injection of 0.5 per cent hydrochloric acid into the stomach in patients with active sensitive ulcer usually produced the characteristic pain. He later claimed this as a specific test for ulcer. In a small group of cases Palmer was able
MEYER J, FETTER D, STRAUSS AA. RELATION OF PAIN OF PEPTIC ULCER TO GASTRIC MOTILITY AND ACIDITY. Arch Intern Med (Chic). 1932;50(2):338–347. doi:10.1001/archinte.1932.00150150170016
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